To john's point the 9mm and .380 have come a long way but you need to research gun and ammo to make sure they fit. My wife's PPK can unleash a world of hurt with a 95grain FMJ FN but only one brand has shot reliably. My daughters Bersa will eat almost anything so there are high penetration (10+ inches) expanding rounds at 90 grain that do the job and she can get 3 shots with great grouping better than the .40